Part of State Highway 1 in Clutha is closed after a serious crash.
Two people have been critically injured in the incident.
Police were called to the incident near Webb Rd on the Waipahi Highway/SH1 about 12.05pm.
Two people have received critical injuries and three have received minor injuries.
The road is blocked while emergency services attend the scene.
Motorists are advised to avoid the area if possible and expect delays.
The crash follows a separate incident on the same highway yesterday, where one person was taken to Dunedin Hospital with serious injuries.